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OCR: Eli Y Adashi MD Professor of Obstetrics/Gynecology & Physiology University of Maryland, School of Medicine Baltimore, Maryland, USA Peter H Bayliss BSc, MD, FRCP Consultant Physician and Professor of Experimental Medicine Endocrine Unit, Royal Victoria Infirmary, and The University of Newcastle upon Tyne, UK Paul E Belchetz MA MD Msc FRCP Senior Lecturer in Medicine and Honorary Consultant Physician University Department of Medicine Royal Liverpool Hospital Liverpool, UK Stephen Bloom MA, MD, FRCP Department of Medicine Hammersmith Hospital London, UK